Persistence pays: how viruses promote host group survival.

Recently, we have realized that viruses numerically dominate all life. Although viruses are known to affect host survival in populations, this has not been previously evaluated in the context of host group selection. Group selection per se is not a currently accepted idea and its apparent occurrence is explained by statistical gene frequency models of kin selection. Viruses were not considered in such models. Prevalent views associate viruses and disease. Yet many viruses establish species-specific persistent, inapparent infections that are stable on an evolutionary time scale. Such persistent infections can have large effects on relative reproductive fitness of competing host populations. In this essay, I present arguments on how persistent infections can promote population survival. Mouse hepatitis virus is used as well studied examplar to re-evaluate the theoretical basis of the mouse haystack model of M Smith. This virus-centric re-examination concludes that viruses can indeed affect and promote relative group selection

Force for ancient and recent life: viral and stem-loop RNA consortia promote life.

Lytic viruses were thought to kill the most numerous host (i.e., kill the winner). But persisting viruses/defectives can also protect against viruses, especially in a ubiquitous virosphere. In 1991, Yarmolinsky et al. discovered the addiction modules of P1 phage, in which opposing toxic and protective functions stabilize persistence. Subsequently, I proposed that lytic and persisting cryptic virus also provide addiction modules that promote group identity. In eukaryotes (and the RNA world), a distinct RNA virus-host relationship exists. Retrovirurses/retroposons are major contributors to eukaryotic genomes. Eukaryotic complexity appears to be mostly mediated by regulatory complexity involving noncoding retroposon-derived RNA. RNA viruses evolve via quasispecies, which contain cooperating, minority, and even opposing RNA types. Quasispecies can also demonstrate group preclusion (e.g., hepatitis C). Stem-loop RNA domains are found in long terminal repeats (and viral RNA) and mediate viral regulation/identity. Thus, stem-loop RNAs may be ancestral regulators. I consider the RNA (ribozyme) world scenario from the perspective of addiction modules and cooperating quasispecies (i.e., subfunctional agents that establish group identity). Such an RNA collective resembles a "gang" but requires the simultaneous emergence of endonuclease, ligase, cooperative catalysis, group identity, and history markers (RNA). I call such a collective a gangen (pathway to gang) needed for life to emerge

Viral Ancestors of Antiviral Systems

All life must survive their corresponding viruses. Thus antiviral systems are essential in all living organisms. Remnants of virus derived information are also found in all life forms but have historically been considered mostly as junk DNA. However, such virus derived information can strongly affect host susceptibility to viruses. In this review, I evaluate the role viruses have had in the origin and evolution of host antiviral systems. From Archaea through bacteria and from simple to complex eukaryotes I trace the viral components that became essential elements of antiviral immunity. I conclude with a reexamination of the ‘Big Bang’ theory for the emergence of the adaptive immune system in vertebrates by horizontal transfer and note how viruses could have and did provide crucial and coordinated features

Brownian motion meets Riemann curvature

The general covariance of the diffusion equation is exploited in order to explore the curvature effects appearing on brownian motion over a d-dimensional curved manifold. We use the local frame defined by the so called Riemann normal coordinates to derive a general formula for the mean-square geodesic distance (MSD) at the short-time regime. This formula is written in terms of $O(d)$ invariants that depend on the Riemann curvature tensor. We study the n-dimensional sphere case to validate these results. We also show that the diffusion for positive constant curvature is slower than the diffusion in a plane space, while the diffusion for negative constant curvature turns out to be faster. Finally the two-dimensional case is emphasized, as it is relevant for the single particle diffusion on biomembranes.Comment: 16 pages and 3 figure

THE RELATIONSHIP BETWEEN JUSTICE PERCEPTIONS, CONSCIENTIOUSNESS AND WORKPLACE BEHAVIORS AMONG OLD AND YOUNG EMPLOYEES

This research addressed the influence employee age has on organizational justice perceptions (OJPs) and organizational citizenship behaviors (OCBs) through conscientiousness. Given the valuable contributions of older employees in the workforce, the aim of this study was to investigate the processes by which age affects justice perceptions, the expression of conscientiousness traits, and workplace behaviors. Additionally, a theoretical framework was provided where the conservation of resource, equity, fairness, socioemotional selectivity, and conscientiousness at work theorieshelp explain the linkages from the integrative model. A total of 179 MTurk workers participated in this study, which required participants to answer questions about their workplace perceptions and behaviors. The primary scales used in this study measuring OJPs, conscientiousness, and OCBs were obtained from previous studies that found these measures to be reliable and valid. Using those scales, three main hypotheses were tested: Hypothesis 1 predicted age would moderate the relationship between OJPs and OCBs; Hypotheses 2 predicted conscientiousness would mediate the relationship between OJPs and OCBs; and Hypothesis 3 predicted employee age (moderating variable) would interact with justice perceptions (independent variable) and predict organizational citizenship behaviors (dependent variable), through conscientiousness (mediating variable). Results suggested that age does not moderate the relationship between OJPs and OCBs; however, conscientiousness mediates the relationship between OJPs and OCBs; and employee age only moderates the mediating effects of conscientiousness in the relationship between distributive justice perceptions and OCBs. Overall, this research provides preliminary findings to a model that had never been researched before, provides theoretical and practical implications, as well as directions for future research

On the sensitivity of extrasolar mass-loss rate ranges: HD 209458b a case study

We present a 3D hydrodynamic study of the effects that different stellar wind conditions and planetary wind structures have on the calculated Ly-$\alpha$ absorptions produced during the transit of HD 209458b. Considering a range of stellar wind speeds $\sim$[350-800] km s$^{-1}$, coronal temperature $\sim$[3-7] $\times10^{6}$ K and two values of the polytropic index $\Gamma$ $\sim$[1.01-1.13], while keeping fixed the stellar mass loss rate, we found a that a $\dot M_p$ range between $\sim$[3-5] $\times 10^{10}$g s$^{-1}$ give account for the observational absorption in Ly-$\alpha$ measured for the planetary system. Also, several models with anisotropic evaporation profiles for the planetary escaping atmosphere were carried out, showing that both, the escape through polar regions and through the night side yields larger absorptions than an isotropic planetary wind

Photo-ionization of planetary winds: case study HD209458b

Close-in hot Jupiters are exposed to a tremendous photon flux that ionizes the neutral escaping material from the planet leaving an observable imprint that makes them an interesting laboratory for testing theoretical models. In this work we present 3D hydrodynamic simulations with radiation transfer calculations of a close-in exoplanet in a blow-off state. We calculate the Ly-$\alpha$ absorption and compare it with observations of HD 209458b an previous simplified model results.Our results show that the hydrodynamic interaction together with a proper calculation of the photoionization proccess are able to reproduce the main features of the observed Ly-$\alpha$ absorption, in particular at the blue-shifted wings of the line. We found that the ionizing stellar flux produce an almost linear effect on the amount of absorption in the wake. Varying the planetary mass loss rate and the radiation flux, we were able to reproduce the $10\%$ absorption observed at $-100~\mathrm{km~s^{-1}}$.Comment: 9 pages, 6 figure

New light curves and ephemeris for the close eclipsing binary V963 PER

We have obtained CCD photometry in 2010-11 of V963 Per (=GSC3355 0394), which is a recently identified close binary star with unequal eclipse depths. The seven new eclipse timings yield an improved ephemeris, but we caution that secondary eclipse can be affected by variation of the light curve. This variation seems to be on a monthly timescale at the few percent level.Comment: 6 pages, 3 figure